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Item number: Cay41170-1

SGK3-PROTAC1 is a proteolysis-targeting chimera (PROTAC) containing the serum/glucocorticoid-regulated kinase 3 (SGK3) inhibitor 308-R conjugated to VHL ligand 1 (Cay-21591) via an alkyl linker with two PEG units. It inhibits SGK3, SGK1, and p70 ribosomal S6 kinase 1 (S6K1, IC50s = 0. 0. and 1. µM, respectively) but...

Keywords:	Serum/Glucocorticoid-regulated Kinase 3-PROTAC1, Serum/Glucocorticoid-regulated Kinase 3-Proteolysis-targeting Chimera 1,...
Application:	SGK3 degradation driving PROTAC
CAS	2381320-35-8
MW:	1157.38 D

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PROTAC SGK3 degrader-1

Item number: TGM-T13847-1mg

Description: PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [CAS ??5017-88-83-4]. Target: SGK, PROTACs. Smiles:...

Keywords:	SGK3-PROTAC1
CAS	2381320-35-8
MW:	1157.38 D

From 38.00€ *

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