2 products were found matching "2380274-50-8"!

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Item number: Cay43318-1

A PROTAC that drives BRM and BRG1 degradation, induces degradation of BRM and BRG1 in HeLa cervical cancer cells at 1 µM but also induces degradation of PBRM1 at the same concentration, decreases proliferation in a panel of 14 cancer cell lines (IC50s = 0.392-28.85 nM), reduces protein levels of FOXA1, ERG, Myc, and...

Keywords:	(2S,4R)-1-((S)-2-(2-(4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydrox...
Application:	BRM / BRG1 degradation driving PROTAC
CAS	2380274-50-8
MW:	755.94 D

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AU-15330

Item number: TGM-T39954-100mg

Description: AU-15330 is a protein hydrolysis-targeted chimeric (PROTAC) degrader of the SWI/SNF ATPase subunits SMARCA2 and SMARCA4.AU-15330 potently inhibits tumor growth in a prostate cancer xenograft model and acts synergistically with the AR antagonist enzalutamide.AU-15330 shows partial therapeutic efficacy...

CAS	2380274-50-8
MW:	755.93 D

From 131.00€ *

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