2 products were found matching "2365172-42-3"!
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DT-2216
Item number: LKT-D760022.1
DT-2216 is a proteolysis targeting chimera degrader which specifically targets Bcl-xL. SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)C(C)NC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCCCC(=O)N4CCN(CC4)CCC(CSC5=CC=CC=C5)NC6=C(C=C(C=C6)S(=O)(=O)NC(=O)C7=CC=C(C=C7)N8CCN(CC8)CC9=C(CCC(C9)(C)C)C1=CC=C(C=C1)Cl)S(=O)(=O)C(F)(F)F)O
| Keywords: | DT2216,... |
| Application: | BCL-XL specific degrader |
| CAS | 2365172-42-3 |
| MW: | 1542.36 D |
From 275.00€
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DT2216
Item number: Cay37311-1
DT2216 is a proteolysis-targeting chimera (PROTAC) composed of the Bcl-2 family inhibitor ABT-263 (Cay-11500) conjugated to a von Hippel-Lindau (VHL) E3 ligase ligand. It selectively induces degradation of Bcl-xL in MOLT-4 T cell acute lymphoblastic leukemia (T-ALL) cells with a 50% degradation concentration (DC50)...
| Keywords: | (2S,4R)-1-((S)-2-(7-(4-((R)-3-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperaz... |
| Application: | Bcl-xL degradation driving PROTAC |
| CAS | 2365172-42-3 |
| MW: | 1542.4 D |
From 36.00€
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