Antibiotic - Antibacteriophage. Antiviral - Mycotoxin - DNA replication, transcription and repair inhibitor - Antibacterial - RNA polymerase and ribonuclease H inhibitor - Insecticidal. Cytotoxic - HIV-1 integrase inhibitor - Shows anti-MRSA (methicillin-resistant Staphylococcus aureus) activity.

(+)-Rugulosin is a pigment and mycotoxin produced by certain fungi. It inhibits HIV-1 integrase activity with IC50 values of 19 and 25 µM in coupled and strand transfer assays, respectively. It also inhibits ribonuclease H in rat liver by 83% at a concentration of 157 µM and ribonucleases H1, H2, and H3 in T....

Yellow solid. Soluble in DMSO, acetone, ethanol or methanol. Mycotoxin, Antibiotic (Streptococcus, Corynebacterium, MRSA), antiviral, HIV-1 integrase inhibitor, DNA replication, transcription and repair inhibitor (carcinogenic activity), RNA polymerase and ribonuclease H inhibitor, insecticidal activity, inhibitor...

Description: Rugulosin (RUG) is a bis-anthraquinoid pigment produced by fungi. Target: Others. Smiles: Cc1cc(O)c2C(=O)C3=C(O)C4[C@H](O)C5[C@@H]6[C@H](O)[C@@H](C(O)=C7C(=O)c8c(O)cc(C)cc8C(=O)[C@@]467)C35C(=O)c2c1. References: Rugulosin. IARC Monogr Eval Carcinog Risk Chem Hum. 1986,40:99-106. PubMed PMID: 3473019.

Rugulosin is an intense yellow pigment produced by some fungal species of Penicillium, Aspergillus and the fungal symbiotants of some lichens. Rugulosin shows antibacterial and insecticidal activity and has found application as a bioinsecticide, notably as the active secondary metabolite in endophytic fungi of...