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IRE1alpha Kinase-IN-1
Item number: Cay43728-10
IRE1alpha kinase-IN-1 is an allosteric inhibitor of inositol-requiring enzyme 1alpha (IRE1alpha, IC50s = 160 and 80 nM for IRE1alpha kinase and ribonuclease activities, respectively). It is selective for IRE1alpha over a panel of 454 wild-type and mutant kinases at 1 µM. IRE1alpha kinase-IN-1 inhibits endoplasmic...
| Keywords: | Inositol-requiring Enzyme 1alpha Kinase Inhibitor 1, Inositol-requiring Enzyme 1alpha Kinase-IN-1, IRE1alpha Kinase... |
| Application: | Allosteric IRE1alpha inhibitor |
| CAS | 2328097-41-0 |
| MW: | 505 D |
From 415.00€
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IRE1alpha kinase-IN-1
Item number: TGM-T9564-100mg
Description: IRE1alpha kinase-IN-1 is a highly selective IRE1alpha (ERN1) inhibitor, with an IC50 of 77 nM, displaying 100-fold selectivity over the IRE1beta isoform. It inhibits ER stress-induced IRE1alpha oligomerization and autophosphorylation, as well as IRE1alpha RNase activity (IC50=80 nM). Target: IRE1....
| CAS | 2328097-41-0 |
| MW: | 504.99 D |
From 111.00€
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