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VZ 185
Item number: Cay41454-1
VZ 185 is a proteolysis-targeting chimera (PROTAC) composed of a von Hippel-Lindau (VHL) ligand and bromodomain-containing protein 7 (BRD7)- and BRD9-binding ligand. It is selective for BRD7 and BRD9 over 6,273 other proteins at 100 nM. VZ 185 degrades BRD7 and BRD9 with half-maximal degradation concentration (DC50)...
| Keywords: | (2S,4R)-N-(2-((5-(4-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4... |
| Application: | BRD7 / BRD9 degradation driving PROTAC |
| CAS | 2306193-61-1 |
| MW: | 995.21 D |
From 91.00€
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VZ185
Item number: TGM-T17249-5mg
Description: VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively). Target: Epigenetic Reader Domain, PROTACs. Smiles: CN1C=C(C=2C(C1=O)=CN=CC2)C3=CC(OC)=C(CN4CCN(CCCCCOC5=C(CNC(=O)[C@H]6N(C([C@@H](NC(=O)C7(F)CC7)C(C)(C)C)=O)C[C@H](O)C6)C=CC(=C5)C=8SC=NC8C)CC4)C(OC)=C3
| CAS | 2306193-61-1 |
| MW: | 995.21 D |
1,004.00€
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