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TD-165
Item number: Cay44837-1
TD-165 is a proteolysis-targeting chimera (PROTAC) that contains VH 032 (Cay-39982) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877). It induces degradation of CRBN in HEK293T cells with a half-maximal degradation concentration (DC50) value of 20. nM. TD-165 (0. µM) increases L-type voltage-gated...
| Keywords: | (2S,4R)-1-((2S)-2-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecanamido)-3,3-dimethyl-butanoyl)-4-... |
| Application: | CRBN degradation driving PROTAC |
| CAS | 2305936-56-3 |
| MW: | 870.08 D |
From 76.00€
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TD-165
Item number: TGM-T18787-100mg
Description: TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1]. Target: PROTACs, Others. Smiles: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCCCCCCC...
| CAS | 2305936-56-3 |
| MW: | 870.07 D |
From 99.00€
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