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Item number: Cay29402-1

DO264 is an inhibitor of alpha/beta-hydrolase domain-containing protein 12 (ABHD12, IC50 = 11 nM). It inhibits ABHD12-dependent hydrolysis of lysophosphatidylserine (lyso-PS) in mouse brain membrane lysates (IC50 = 2.8 nM) and human THP-1 cells. DO264 increases levels of chemokine (C-C motif) ligand 3 (CCL3), CCL4,...

Keywords:	N-[1-[3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]-2-pyridinyl]-4-piperidinyl]-N'-3-pyridinyl-thiourea
Application:	Lysophosphatidylserine lipase ABHD12 inhibitor
CAS	2301866-59-9
MW:	558.4 D

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DO-264

Item number: TGM-T11069-1mg

Description: DO-264 is an inhibitor of autohydrolase structural domain 12 (ABHD12) (IC50: 11 nM) and an inhibitor of cellular LysoPS degradation that enhances LPS-induced phagocytosis. Target: Others. Smiles: FC(F)(F)Oc1ccc(Oc2ccnc(N3CCC(CC3)NC(=S)Nc3cccnc3)c2Cl)c(Cl)c1. References: Ogasawara D, et al. Selective...

CAS	2301866-59-9
MW:	558.4 D

From 49.00€ *

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