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VT103
Item number: Cay42327-1
A TEAD1 inhibitor (IC50 = 1.02 nM), inhibits TEAD autopalmitoylation in HEK293 cells expressing TEAD1 but not HEK293 cells expressing TEAD2, TEAD3, or TEAD4 at 3 µM, inhibits palmitoylation of endogenous TEAD1 in NCI-H2373 cells, reduces tumor volume in NCI-H2373 and NCI H226 mesothelioma mouse xenograft models....
| Keywords: | N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]amino]-benzenesulfonamide |
| Application: | TEAD1 inhibitor |
| CAS | 2290608-13-6 |
| MW: | 410.41 D |
From 112.00€
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VT103
Item number: TGM-T62077-100mg
Description: VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP/TAZ-TEAD-promoted gene transcriptionment, blocking TEAD auto-palmitoylation, and blocking the interaction between YAP/TAZ and TEAD.VT103...
| Keywords: | VT-103 , VT 103 |
| CAS | 2290608-13-6 |
| MW: | 410.41 D |
From 119.00€
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