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Item number: TGM-T78876-100mg

Description: DNL343 is a selective and potent eIF2B activator that crosses the blood-brain barrier and inhibits the assembly of stress granules (SGs) induced by the C9ORF72 dipeptide repeats. DNL343 may be useful in the study of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). Target: PERK....

Keywords:	DNL 343, DNL-343
CAS	2278265-85-1
MW:	457.83 D

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DNL343

Item number: Cay41674-1

DNL343 is an activator of eukaryotic translation initiation factor 2B (eIF2B, IC50 = 9.8 nM in a reporter assay) and a derivative of 2BAct (Cay-37788). It inhibits sodium arsenite-induced formation of stress granules positive for TAR DNA-binding protein 43 (TDP-43) in an in vitro model of amyotrophic lateral...

Keywords:	2-(4-chlorophenoxy)-N-[3-[5-[cis-3-(trifluoromethoxy)cyclobutyl]-1,3,4-oxadiazol-2-yl]bicyclo[1.1.1]pent-1-yl]-acetamide
Application:	EIF2B activator
CAS	2278265-85-1
MW:	457.8 D

From 127.00€ *

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