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MDL-800
Item number: TGM-T64529-100mg
Description: MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer. Target: Sirtuin. Smiles: COC(=O)c1cc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)ccc1S(=O)(=O)Nc1cc(Br)c(F)cc1C. References: Shang JL, et al. MDL-800, an allosteric activator of SIRT6,...
| Keywords: | MDL800, MDL 800 |
| Application: | Allosteric SIRT6 activator |
| CAS | 2275619-53-7 |
| MW: | 626.3 D |
From 52.00€
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MDL 800
Item number: Cay35528-5
MDL 800 is an allosteric activator of sirtuin 6 (SIRT6). It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation (IC50 = 23.3 µM) in, and reduces proliferation of,...
| Keywords: | 2-[[(5-bromo-4-fluoro-2-methylphenyl)amino]sulfonyl]-5-[[(3,5-dichlorophenyl)sulfonyl]amino]-benzoic acid, methyl ester |
| Application: | Allosteric SIRT6 activator |
| CAS | 2275619-53-7 |
| MW: | 626.3 D |
From 69.00€
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