An orexin receptor 2 agonist, selectively induces calcium mobilization in CHO-K1 cells expressing human OX2R over those expressing OX1R (EC50s = 0.019 and 14 µM, respectively), selective for OX2R over a panel of 106 enzymes, receptors, and ion channels at 10 µM, increases wakefulness time and wakefulness episode...

Description: Firazorexton is a potent orexin type 2 receptor (OX2R) agonist. Target: Others. Smiles: CC(C)(O)C(=O)N1CC[C@H](NS(C)(=O)=O)[C@@H]1Cc1cccc(c1F)-c1cc(F)cc(F)c1. References: Yuichi Kajita, et al. Heterocyclic compound and use thereof. WO2019027058A1.