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Item number: Cay45588-1

HC-5404 is an inhibitor of protein kinase R-like ER kinase (PERK, IC50 = 4 nM in a cell-free assay). It is selective for PERK over a panel of 25 kinases at 1 mM. HC-5404 reduces the levels of phosphorylated eukaryotic translation initiation factor 2alpha subunit (eIF2alpha) in HEK293 cells (IC50 = 33 nM). It reduces...

Keywords:	LY-4,...
Application:	PERK (EIF2AK3) inhibitor
CAS	2247396-91-2
MW:	454.48 D

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