MLCK inhibitor peptide 18 is a cell-permeable inhibitor of myosin light chain kinase (MLCK, IC50 = 50 nM) with 4,000-fold selectivity for MLCK over CaM kinase II and PKA. It prevents defects in transepithelial barrier resistance induced by bacteria or TNF-alpha plus IFN-gamma. MLCK inhibitor peptide 18 prevents...

Description: Selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable. References: Lukas et al (1999) Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based...