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BAY-293
Item number: TGM-T5418-100mg
Description: BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM). Target: Raf, Ras. Smiles: CNCc1ccccc1-c1csc(c1)[C@@H](C)Nc1nc(C)nc2cc(OC)c(OC)cc12. References: Hillig RC, et al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the...
| Application: | The K-Ras-SOS1 protein-protein interaction inhibitor |
| CAS | 2244904-70-7 |
| MW: | 448.58 D |
From 48.00€
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BAY-293
Item number: Cay33606-1
BAY-293 is an inhibitor of the protein-protein interaction between K-Ras and the guanine nucleotide exchange factor son of sevenless homolog 1 (SOS1, IC50 = 0.021 µM). It inhibits proliferation of K562 and MOLM-13 cells expressing wild-type K-Ras, as well as NCI H358 and Calu-1 cells expressing mutant K-RasG12C with...
| Keywords: | 6,7-dimethoxy-2-methyl-N-[(1R)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-4-quinazolinamine |
| Application: | The K-Ras-SOS1 protein-protein interaction inhibitor |
| CAS | 2244904-70-7 |
| MW: | 448.6 D |
From 78.00€
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