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FB23
Item number: TGM-T8874-100mg
Description: FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.). Target: Others. Smiles: Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2C(O)=O)c(Cl)c1. References: Small-molecule targeting of oncogenic FTO...
| Application: | FTO inhibitor |
| CAS | 2243736-35-6 |
| MW: | 377.22 D |
From 45.00€
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FB23
Item number: Cay37383-1
FB23 is an inhibitor of the mRNA N6-methyladenosine (m6A) demethylase fat mass and obesity-associated (FTO) protein (IC50 = 0.06 µM) and an active metabolite of FB23-2 (Cay-36606). It reduces the proliferation of NB4 and Mono-Mac-6 acute myeloid leukemia (AML) cells (IC50s = 44.8 and 23.6 µM, respectively).Formal...
| Keywords: | 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-benzoic acid |
| Application: | FTO inhibitor |
| CAS | 2243736-35-6 |
| MW: | 377.2 D |
From 45.00€
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