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Item number: Cay42513-1

DCZ0415 is an inhibitor of thyroid hormone receptor interactor 13 (TRIP13). It binds to TRIP13 (Kd = 2. µM) and reduces non-homologous end joining (NHEJ) repair of DNA in a reporter assay. DCZ0415 (10 and 20 µM) impairs DNA repair in ARP-1 and NCI H929 multiple myeloma cells. It reduces the growth of a variety of...

Keywords:	4,4a,5,5a,6,6a-hexahydro-2-[4-(4-pyridinylmethyl)phenyl]-4,6-ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione
Application:	TRIP13 inhibitor
CAS	2242470-43-3
MW:	356.42 D

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DCZ0415

Item number: TGM-T10981-100mg

Description: DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can impair the repair of non-homologous end junctions and inhibit NF-kappaB activity. Target: NF-kappaB, Others, Apoptosis. Smiles:...

CAS	2242470-43-3
MW:	356.42 D

From 46.00€ *

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