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BI-3406
Item number: TGM-T12979-100mg
Description: BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity. Target: Ras, p38 MAPK, MAPK. Smiles: COc1cc2nc(C)nc(N[C@H](C)c3cc(N)cc(c3)C(F)(F)F)c2cc1O[C@H]1CCOC1. References: Marco H Hofmann, et al....
| Application: | The K-Ras-SOS1 protein-protein interaction inhibitor |
| CAS | 2230836-55-0 |
| MW: | 462.46 D |
From 67.00€
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BI-3406
Item number: Cay35261-5
BI-3406 is an inhibitor of the protein-protein interaction between K-Ras and the guanine nucleotide exchange factor son of sevenless homolog 1 (SOS1, IC50 = 5 nM). It selectively disrupts the protein-protein interaction between K-RasG12C or K-RasG12D with SOS1 over SOS2, and it is selective over 321 kinases in a...
| Keywords: | N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinamine |
| Application: | The K-Ras-SOS1 protein-protein interaction inhibitor |
| CAS | 2230836-55-0 |
| MW: | 462.5 D |
From 85.00€
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