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(R,S,S)-VH 032
Item number: Cay44838-10
A diastereomer of VHL ligand 1, (R,S,S)-VH 032-containing molecules bind targets with the same affinity as PROTACs utilizing VHL ligand 1 but do not induce target degradation, have been used as controls for VHL ligand 1-containing PROTAC degradation activity. SMILES:...
| Keywords: | (4S)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-D-prolinamide |
| Application: | VHL ligand 1 (PROTAC building block) diastereomer |
| CAS | 2230826-33-0 |
| MW: | 430.57 D |
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(R,S,S)-VH032
Item number: TGM-T84747-10mg
Description: (R,S,S)-VH032 is a ligand for E3 ligase and a VHL/HIF-1alpha interaction inhibitor utilized in the synthesis of PROTACs, particularly the tau-targeting small molecule PROTAC C004019 [1]. As a VHL ligand, it recruits von Hippel-Lindau (VHL) proteins, facilitating the development of targeted protein...
| CAS | 2230826-33-0 |
| MW: | 430.56 D |
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