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Item number: Cay28597-1

Gefitinib-based PROTAC 3 is a proteolysis-targeting chimera (PROTAC) comprised of the EGF receptor (EGFR) inhibitor gefitinib (Cay-13166) linked to the von Hippel-Lindau (VHL) E3 ubiquitin ligase ligand VHL ligand 1 (Cay-21591). In cell-based assays, gefitinib-based PROTAC 3 induces degradation of EGFR containing...

Keywords:	Gefitinib-based Proteolysis-targeting Chimera 3,...
Application:	EGFR-L858R degradation
CAS	2230821-27-7
MW:	934.5 D

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Gefitinib-based PROTAC 3

Item number: BPS-82059

Gefitinib-based PROTAC 3 contains an EGFR binding element and a von Hippel-Lindau ligand joined by a linker which induces EGFR degradation.

Application:	Protac(R) reagent
CAS	2230821-27-7
MW:	934,5 D

710.00€ *

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