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ARV-471
Item number: Cay43002-1
ARV-471 is a proteolysis-targeting chimera (PROTAC) containing a derivative of the estrogen receptor (ER) modulator lasofoxifene conjugated to the immunomodulatory cereblon ligand lenalidomide (Cay-14643). It induces degradation of ER in MCF-7 breast cancer cells with a half-maximal degradation concentration (DC50)...
| Keywords: | Vepdegestrant,... |
| Application: | ER degradation driving PROTAC |
| CAS | 2229711-68-4 |
| MW: | 723.92 D |
From 410.00€
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ARV-471
Item number: TGM-T39710-10mg
Description: ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer. Target: Estrogen Receptor/ERR, PROTACs. Smiles:...
| Keywords: | Vepdegestrant |
| Application: | Targets estrogen receptor alpha (ESR1, NR3A1) |
| CAS | 2229711-68-4 |
| MW: | 723.9 D |
From 264.00€
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