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Item number: Cay45370-10

Dynapyrazole-A is an inhibitor of the motor proteins dynein 1 and dynein 2. It inhibits the microtubule-stimulated ATPase activity of dynein but not its basal microtubule-independent activity. Dynapyrazole-A inhibits dynein 1- and dynein 2-mediated microtubule gliding in a cell-free assay (IC50s = 2.3 and 2.6 µM,...

Keywords:	2-[1-(4-chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxo-pyrazolo[1,5-a]quinazoline-3-carbonitrile
Application:	Dynein 1 / dynein 2 inhibitor
CAS	2226517-75-3
MW:	486.7 D

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Dynapyrazole A

Item number: TGM-T35548-1mL

Description: Dynapyrazole A is a specific inhibitor of microtubule dynamin with IC50s of 2.3 and 2.6 µM for dynein 1 and dynein 2-dependent microtubule gliding, and it inhibits Hedgehog signaling with an IC50 of 1.9 µM. Target: Dynamin. Smiles: Clc1ccc(cc1)C1(CC1)c1nn2c([nH]c(=O)c3cc(I)ccc23)c1C#N. References:...

CAS	2226517-75-3
MW:	486.69 D

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