Description: BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 µM (pH7.5) for Arginase II, and is 0.4-0.6 µM for rat Arginase I. Target: Arginase. Smiles: Cl.NC(CSCCB(O)O)C(O)=O. References: Colleluori DM, et al. Biochemistry. 2001, 40(31), 9356-9362.

BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses. It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1...