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Item number: Cay13330-10

1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28...

Keywords:	PP1 Analog II, 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Application:	Analog-sensitive kinase inhibitor
CAS	221244-14-0
MW:	331.4 D

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1-NM-PP1

Item number: TGM-T2153-100mg

Description: 1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. Target: CDK, Serine/threonin kinase, Src. Smiles: CC(C)(C)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc12. References: Larochelle S, et al. Requirements for Cdk7...

Keywords:	PP1 Analog II, 1 nM-PP1
CAS	221244-14-0
MW:	331.41 D

From 41.00€ *

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