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GW-406381
Item number: TGM-T15449-100mg
Description: GW406381 is a highly selective inhibitor of cyclooxygenase-2 (COX-2). GW406381 also attenuates spontaneous ectopic discharge in the sural nerves of rats following chronic constriction injury. Target: COX. Smiles: CCOc1ccc(cc1)-c1nn2ncccc2c1-c1ccc(cc1)S(C)(=O)=O. References: Zhao FY, et al. GW406381, a...
| Application: | NSAID, COX-2 inhibitor |
| CAS | 221148-46-5 |
| MW: | 393.46 D |
From 754.00€
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GW 406381
Item number: Cay33895-1
GW 406381 is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50 = 3 nM). It is selective for COX-2 over COX-1 (IC50 = >84.2 µM). GW 406381 (5 mg/kg) reverses chronic construction injury-induced decreases in paw withdrawal thresholds in a rat model of neuropathic pain.Formal Name:...
| Keywords: | GW406381X, 2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine |
| Application: | NSAID, COX-2 inhibitor |
| CAS | 221148-46-5 |
| MW: | 393.5 D |
From 44.00€
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