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Item number: TGM-T9050-100mg

Description: AG-270 is an allosteric and orally active inhibitor of MAT2A. Target: Others, Methionine Adenosyltransferase (MAT). Smiles: COc1ccc(cc1)-c1c(Nc2ccccn2)[nH]c2c(c(nn2c1=O)-c1ccccc1)C1=CCCCC1. References: Zenon Konteatis, et al. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment...

Application:	MAT2A (S-adenosylmethionine synthetase) inhibitor
CAS	2201056-66-6
MW:	489.57 D

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AG-270

Item number: Cay36246-10

AG-270 is an inhibitor of methionine adenosyltransferase 2A (MAT2A, IC50 = 0.014 µM). It reduces levels of S-(5'-adenosyl)-L-methonine (SAM, Cay-16376, Cay-17595) in, and inhibits the proliferation of, HCT116 cells with a homozygous deletion of MTAP, the gene encoding methylthioadenosine phosphorylase (IC50s = 0.2...

Keywords:	3-(1-cyclohexen-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-(2-pyridinylamino)-pyrazolo[1,5-a]pyrimidin-7(4H)-one
Application:	MAT2A (S-adenosylmethionine synthetase) inhibitor
CAS	2201056-66-6
MW:	489.6 D

From 305.00€ *

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