Description: Lenacapavir (GS-6207) is a potent capsid-targeting inhibitor of HIV replication, demonstrating anti-HIV activity with an EC50 of 100 pM in MT-4 cells. Target: HIV Protease, Others. Smiles:...

An inhibitor of HIV capsid protein-protein interactions, inhibits viral replication in HIV-1-infected primary human CD4+ T cells and macrophages (mean IC50s = 32 and 56 pM, respectively), two HIV-2 clinical isolates (mean IC50 = 885 pM), and 23 HIV-1 clinical isolates (mean IC50 = 50 pM), prevents stHIV-A19...