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Item number: Cay35897-5

GCN2iB is an inhibitor of general control nonderepressible 2 kinase (GCN2, IC50 = 2.4 nM). It is selective for GCN2 over a panel of 465 kinases but does inhibit MAP2K5, eukaryotic translation initiation factor 2alpha kinase 2 (EIF2AK2), and MAP3K20 at 1 µM. GCN2iB (1 µM), in combination with L-aspariginase, reduces...

Keywords:	N-[3-[2-(2-amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide
Application:	EIF2AK4 (GCN2) inhibitor
CAS	2183470-12-2
MW:	451.8 D

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GCN2iB

Item number: TGM-T11375-100mg

Description: GCN2iB, an ATP-competitive inhibitor of general control nonderepressible 2 (GCN2), exhibits an IC50 of 2.4 nM. Target: Autophagy, Others. Smiles: COc1ncc(Cl)cc1S(=O)(=O)Nc1ccc(F)c(C#Cc2cnc(N)nc2)c1F. References: Nakamura A, et al. Inhibition of GCN2 sensitizes ASNS-low cancer cells by disrupting the...

CAS	2183470-12-2
MW:	451.83 D

From 73.00€ *

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