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YKL-06-061
Item number: TGM-T5576-100mg
Description: YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively. Target: SIK, AMPK. Smiles: COc1cc(ccc1Nc1ncc2CN(C(=O)N(C3CCC3)c2n1)c1c(C)cccc1C)N1CCN(C)CC1. References: Mujahid N, et al. A UV-Independent Topical Small-Molecule...
| CAS | 2172617-15-9 |
| MW: | 527.66 D |
From 30.00€
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YKL-06-061
Item number: Cay41721-10
YKL-06-061 is an inhibitor of salt-inducible kinase 1 (SIK1), SIK2, and SIK3 (IC50s = 6.56, 1.77, and 20.5 nM, respectively). It is selective for these SIKs over a panel of 468 additional kinases at 1 µM but does inhibit FRK, CSF1R, p38alpha, p38beta, EphB1, and TNK2 (IC50s = 1.1, 9.66, 10.1, 9.64, 16.4, and 10.5...
| Keywords: | 1-cyclobutyl-3-(2,6-dimethylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-pyrimido[4,5-d]pyrim... |
| Application: | Salt-inducible kinase (SIK1, SIK2, SIK3) inhibitor |
| CAS | 2172617-15-9 |
| MW: | 527.7 D |
From 112.00€
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