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dTRIM24
Item number: Cay45749-1
dTRIM24 is a proteolysis-targeting chimera (PROTAC) containing the ubiquitin ligase TRIM24 ligand IACS-7e conjugated to the von Hippel-Lindau (VHL) ligand VL-269 via a PEG linker. It induces degradation of TRIM24 in HEK293-FT cells at 0.25-5 µM with maximum degradation at 5 µM. dTRIM24 (5 µM) reduces growth and...
| Keywords: | (2S,4R)-1-((S)-15-(tert-butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfa... |
| Application: | TRIM24 degradation driving PROTAC |
| CAS | 2170695-14-2 |
| MW: | 1113.31 D |
From 116.00€
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dTRIM24
Item number: TGM-T15178-10mg
Description: dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24. Target: PROTACs, Others. Smiles: O(C1=C(NS(=O)(=O)C2=CC(C(NCCOCCOCCO...
| CAS | 2170695-14-2 |
| MW: | 1113.3 D |
From 73.00€
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