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Item number: Cay37309-10

PZ-2891 is a modulator of pantothenate kinase (PanK). It selectively inhibits PanK1beta, PanK2, and PanK3 (IC50s = 40.2, 0.7, and 1.3 nM, respectively) in the absence of acetyl-CoA over 468 other kinases and a panel of 72 receptors and ion channels at 10 µM. PZ-2891 (2.5 µM) reverses acetyl-CoA-induced inhibition of...

Keywords:	Pantazine 2891, 6-[4-[2-[4-(1-methylethyl)phenyl]acetyl]-1-piperazinyl]-3-pyridazinecarbonitrile
Application:	Pantothenate kinase modulator
CAS	2170608-82-7
MW:	349.4 D

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PZ-2891

Item number: TGM-T5185-100mg

Description: PZ-2891 is an orally bioavailable, brain-penetrant pantothenate kinase (PANK) modulator, with an IC50 of 1.3 nM for hPANK3. Target: Others. Smiles: CC(C)c1ccc(CC(=O)N2CCN(CC2)c2ccc(nn2)C#N)cc1. References: Lalit, Kumar, Sharma, et al. A therapeutic approach to pantothenate kinase associated...

Application:	Pantothenate kinase modulator
CAS	2170608-82-7
MW:	349.43 D

From 33.00€ *

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