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Item number: Cay18718-1

RWJ 67657 is an orally active inhibitor of the MAP kinases p38alpha and p38beta (IC50s = 1 and 11 µM, respectively, in vitro) that is inactive against p38gamma and p38delta, as well as several other kinases. It blocks the release of TNF-alpha and IL-1beta from peripheral blood mononuclear cells stimulated with LPS...

Keywords:	JNJ-3026582, 4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol
Application:	p38 alpha inhibitor, p38 beta inhibitor
CAS	215303-72-3
MW:	425.5 D

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RWJ-67657

Item number: SYN-1072-M001

Soluble in DMSO or ethanol. The cytokine Tumor necrosis factor-alpha (TNF-alpha) is secreted by activated monocytes/macrophages and T lymphocytes and has been implicated in several disease states, including rheumatoid arthritis, inflammatory bowel disease, septic shock, and osteoporosis. Monocyte/macrophage...

Keywords:	RWJ67657
Application:	p38 inhibitor
CAS	215303-72-3
MW:	425,5 D

From 66.00€ *

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