1400W is a potent, selective inhibitor of iNOS. Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively. In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS. In mice bearing a murine mammary carcinoma, continuous infusion of 1400W...

A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd &le, 7 nM), Weak and reversible inhibition of nNOS (neuronal nitric oxide synthase/NOS I) (Ki &le, 2) and eNOS (endothelial nitric oxide synthase/NOS III) (Ki &le, 50 µM), Inhibits tumor growth, Increases...