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2BAct
Item number: TGM-T9149-100mg
Description: 2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response. Target: PERK. Smiles: FC(F)c1cnc(cn1)C(=O)NC12CC(C1)(C2)NC(=O)COc1ccc(Cl)c(F)c1. References: Wong YL, LeBon L, Basso AM, Kohlhaas KL, Nikkel AL, Robb HM, Donnelly-Roberts DL, Prakash J,...
| Keywords: | 2B-Act, 2B Act |
| Application: | EIF2B activator |
| CAS | 2143542-28-1 |
| MW: | 440.8 D |
From 50.00€
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2BAct
Item number: Cay37788-1
2BAct is an activator of eukaryotic translation initiation factor 2B (eIF2B, EC50 = 33 nM in a reporter assay). It enhances eIF2B activity in primary fibroblasts isolated from Eif2b5R191H mutant (R191H) mouse embryos (EC50 = 7.3 nM), a model of vanishing white matter (VWM) leukodystrophy. In vivo, 2BAct (30 mg/kg)...
| Keywords: | N-[3-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]bicyclo[1.1.1]pent-1-yl]-5-(difluoromethyl)-2-pyrazinecarboxamide |
| Application: | EIF2B activator |
| CAS | 2143542-28-1 |
| MW: | 440.8 D |
From 116.00€
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