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Item number: Cay43138-10

VU6005649 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 7 (mGluR7) and mGluR8. It enhances calcium mobilization induced by L-AP4 (Cay-14538) in HEK cells expressing mGluR7 or mGluR8 (EC50s = 0. and 2. µM, respectively). It is selective for mGluR7 and mGluR8 over mGluR1-6, as well as a...

Keywords:	3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine
Application:	Positive allosteric mGluR7 / mGluR8 modulator
CAS	2137047-43-7
MW:	357.28 D

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