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Ziftomenib
Item number: Cay45139-10
An inhibitor of the menin-MLL1 protein-protein interaction, reduces the viability of OCI-AML-3 and MV4-11 cells, reduces the viability of MOLM-13 cells expressing p53R175H and TP53-/- MOLM-13 cells over MOLM-13 cells expressing wild-type p53, increases survival in a PDX mouse model of AML at 75 mg/kg. SMILES:...
| Keywords: | KO-539, 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]... |
| Application: | Menin-MLL1 protein-protein interaction inhibitor |
| CAS | 2134675-36-6 |
| MW: | 717.88 D |
From 438.00€
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Ziftomenib
Item number: TGM-T39585-100mg
Description: Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity, suitable for leukemia research. Target: Epigenetic Reader Domain, Histone Methyltransferase. Smiles: CNc1nc(NC2CCN(Cc3ccc4n(C[C@H](C)N5CCN(CC5)S(C)(=O)=O)c(cc4c3C)C#N)CC2)c2cc(CC(F)(F)F)sc2n1
| Keywords: | KO-539 |
| Application: | Targets menin (MEN1, MNN1) |
| CAS | 2134675-36-6 |
| MW: | 717.871 D |
From 108.00€
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