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Item number: Cay43171-10

BIRT 377 is a negative allosteric modulator (NAM) of lymphocyte function-associated antigen-1 (LFA-1). It binds to LFA-1 at a site distal to residues involved in intercellular adhesion molecule interactions and induces a conformational change to its inactive state. BIRT 377 selectively inhibits the interaction of...

Keywords:	(5R)-5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
Application:	Negative allosteric lymphocyte function-associated antigen-1 (LFA-1) modulator
CAS	213211-10-0
MW:	442.13 D

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BIRT-377

Item number: TGM-T23796-100mg

Description: BIRT-377 is a negative allosteric and orally bioavailable inhibitor of ICAM-1 and LFA-1(Ki = 25.8 nM). BIRT-377 inhibits the production of IL-2 and can be used in studies about inflammatory and immune disorders. Target: Integrin, IL Receptor. Smiles:...

Keywords:	BIRT377, BIRT 377
CAS	213211-10-0
MW:	442.13 D

From 48.00€ *

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