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VU0661013
Item number: TGM-T17247-100mg
Description: VU0661013 is an effective and selective inhibitor of MCL-1. Target: BCL. Smiles: C[C@@H]1CN(c2cn(C)c3ccc(cc23)C(O)=O)C(=O)c2c(CCCOc3cc(C)c(Cl)c(C)c3)c3ccc(Cl)c(-c4c(C)nn(C)c4C)c3n12. References: Haley E. Ramsey, et al. A Novel MCL-1 Inhibitor Combined with Venetoclax Rescues Venetoclax Resistant Acute...
| Keywords: | VU661013 |
| Application: | Mcl-1 inhibitor |
| CAS | 2131184-57-9 |
| MW: | 712.66 D |
From 63.00€
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VU0661013
Item number: Cay39524-1
VU0661013 is an inhibitor of myeloid cell leukemia-1 (Mcl-1, Ki = 97 pM). It is selective for Mcl-1 over Bcl-xL and Bcl-2 (Kis = >40 and 0.73 µM, respectively). VU0661013 inhibits cell growth in a panel of acute myeloid leukemia (AML) cell lines (GI50s = 0.16-7.62 µM). It decreases blood, bone marrow, and spleen...
| Keywords: | 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,4-dihydro-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl... |
| Application: | Mcl-1 inhibitor |
| CAS | 2131184-57-9 |
| MW: | 712.7 D |
From 136.00€
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