2 products were found matching "2127109-84-4"!
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PF-06826647
Item number: Cay37577-1
PF-06826647 is an inhibitor of tyrosine kinase 2 (TYK2, IC50 = 15 nM). It is selective for TYK2 over JAK1, JAK2, and JAK3 (IC50s = 383, 74, and >10,000 nM, respectively). PF-06826647 inhibits IL-12-induced phosphorylation of STAT4 in isolated human whole blood (IC50 = 14 nM). In vivo, PF-06826647 (3-30 mg/kg, p.o.)...
| Keywords: | Ropsacitinib, TYK2 Inhibitor 8, TYK2-IN-8,... |
| Application: | TYK2 inhibitor |
| CAS | 2127109-84-4 |
| MW: | 383.4 D |
From 81.00€
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Ropsacitinib
Item number: TGM-T13237L-10mg
Description: Ropsacitinib (PF-06826647) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM). Target: Tyrosine Kinases. Smiles: C(C#N)[C@@]1(C[C@H](C#N)C1)N2C=C(C=N2)C=3C=4N(C=C(N3)C=5C=NN(C)C5)N=CC4. References: Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine...
| Keywords: | Tyk2-IN-8, PF-06826647 |
| Application: | Targets non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2] (TYK2) |
| CAS | 2127109-84-4 |
| MW: | 383.41 D |
From 242.00€
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