An HDAC6 inhibitor (IC50 = 7.1 nM), selective for HDAC6 over ten other HDAC isoforms (IC50s = 3.46-32.8 µM), ) increases the levels of acetylated alpha-tubulin in HEK293 cells at 10 µM, prevents deficits in the novel object recognition test in Fmrp knockout mice at 20 mg/kg twice per day

Description: SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the blood-brain-barrier. Target: HDAC. Smiles: ONC(=O)c1ccc(CN2CCCc3cc(Cl)ccc23)cc1....