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Item number: Cay45472-1

Eclitasertib is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1, IC50 = 0.0375 µM). It inhibits necroptosis induced by TNF-alpha, a Smac mimetic, and Z-VAD-FMK in HT-29 cells (EC50 = 0.0154 µM, respectively). Eclitasertib (4 nM) inhibits necroptosis induced by IFN-gamma, TNF-alpha, Z-VAD, and...

Keywords:	DNL758, SAR443122,...
Application:	RIPK1 inhibitor
CAS	2125450-76-0
MW:	378.39 D

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Eclitasertib

Item number: TGM-T9702-100mg

Description: Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µ?). Target: RIP kinase. Smiles: CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O. References: Anthony A. ESTRADA, et al. Compounds, compositions and methods. WO2017136727A2.

Application:	Targets receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1] (RIPK1, RIP1)
CAS	2125450-76-0
MW:	378.38 D

From 102.00€ *

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