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ZT-1a
Item number: Cay45727-1
ZT-1a is an inhibitor of STE20/SPS1-related proline-alanine-rich protein kinase (SPAK, IC50 = 46.7 µM in a cell-free assay). It reduces phosphorylation of Na-K-Cl cotransporter 1 (NKCC1), Na-K cotransporter 2 (KCC2), and KCC3 in HEK293 cells. ZT-1a reduces cerebrospinal fluid (CSF) hypersecretion in a rat model of...
| Keywords: | 5-chloro-N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-benzamide |
| Application: | SPAK inhibitor |
| CAS | 212135-62-1 |
| MW: | 445.72 D |
From 69.00€
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ZT-1a
Item number: TGM-T39566-10mg
Description: ZT-1a is a SPAK inhibitor.ZT-1a inhibits SPAK.ZT-1a can be used for the prevention and treatment of neurodegenerative and neurocognitive disorders. Target: Others. Smiles: Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(Cl)ccc1O. References: Zhang J,et al. Modulation of brain cation-Cl- cotransport via the...
| CAS | 212135-62-1 |
| MW: | 445.73 D |
From 70.00€
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