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Sobetirome
Item number: TGM-T5313-100mg
Description: Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor beta (TRbeta) and binds selectively to TRbeta-1 (EC50: 0.16 µM). Target: Thyroid hormone receptor(THR). Smiles: CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)ccc1O. References: Gierach I, et al. Bacterial biosensors for screening...
| Keywords: | QRX-431, GC 1, GC-1, IACS-010759, GC1 |
| Application: | Targets thyroid hormone receptor beta (THRB, NR1A2) |
| CAS | 211110-63-3 |
| MW: | 328.4 D |
From 42.00€
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Sobetirome
Item number: Cay30814-1
Sobetirome is an agonist of thyroid hormone receptor beta (TRbeta, EC50 = 7 nM in a reporter assay). It selectively binds to TRbeta over TRalpha with Kd values of 0.1 and 1.8 nM, respectively. Sobetirome (97 nmol/kg, i.p.) increases hepatic levels of the HDL receptor SR-B1 and serum levels of C4, a marker of...
| Keywords: | GC-1, QRX 431, 2-[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]-acetic acid |
| Application: | Thyroid hormone receptor beta (Trbeta) agonist |
| CAS | 211110-63-3 |
| MW: | 328.4 D |
From 54.00€
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