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Sitaxentan (sodium salt)
Item number: Cay29244-5
Sitaxentan is a potent nonpeptide endothelin A (ETA) receptor antagonist (IC50 = 1.4 nM). It is selective for ETA over ETB receptors (IC50 = 9,800 nM). Sitaxentan inhibits phosphoinositol hydrolysis induced by endothelin-1 (Cay-24127) in COS-7 cells (pA2 = 8). In vivo, sitaxentan reduces blood pressure in a rat...
| Keywords: | TBC 11251, Thelin, N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide,... |
| Application: | Potent endothelin A receptor antagonist |
| CAS | 210421-74-2 |
| MW: | 476.9 D |
From 68.00€
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Sitaxsentan sodium
Item number: TGM-T6672-100mg
Description: Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors. Target: Endothelin Receptor. Smiles: [Na+].Cc1noc([N-]S(=O)(=O)c2ccsc2C(=O)Cc2cc3OCOc3cc2C)c1Cl. References: Tilton RG, et al. Pulm Pharmacol Ther. 2000, 13(2), 87-97.
| Keywords: | TBC11251 sodium salt , TBC11251 , Thelin , Sitaxentan sodium |
| Application: | Targets endothelin receptor type A (EDNRA) |
| CAS | 210421-74-2 |
| MW: | 476.89 D |
From 30.00€
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