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Item number: AG-CR1-0081-C250
Cell permeable, potent, selective, non-transition state and non-competitive and gamma-secretase inhibitor. Notch processing inhibitor. Only weakly affects presenilinase activity.
Item number: Cay15579-1
gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...
|Keywords:||gamma-Secretase Inhibitor XXI,...|