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BLU-667
Item number: LKT-B465806.1
BLU-667 is an inhibitor of the rearranged during transfection (RET) kinase. RET is an oncogenic driver activated in multiple cancers. BLU-667 is an early selective small molecule designed to target RET, in contrast with current treatment methods that have been limited to multikinase inhibitors. BLU-667 potently...
| Keywords: | BLU 667, BLU667, Pralsetinib,... |
| Application: | RET inhibitor |
| CAS | 2097132-94-8 |
| MW: | 533.61 D |
From 143.00€
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Pralsetinib
Item number: TGM-TQ0277-1mg
Description: Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion). Target: c-RET. Smiles: CO[C@]1(CC[C@@H](CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1. References:...
| Keywords: | Blu667 |
| Application: | Targets proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1] (RET) |
| CAS | 2097132-94-8 |
| MW: | 533.6 D |
From 37.00€
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Pralsetinib
Item number: Cay33181-1
Pralsetinib is an inhibitor of RET (IC50s = 0.4, 0.3, 0.4, and 0.4 nM for wild-type RET, RETV804L, RETV804M, and RETM918T, respectively). It is selective for RET over VEGFR2 (IC50 = 35 nM) and a panel of 371 kinases at 300 nM. Pralsetinib also inhibits a fusion protein of coiled-coil domain-containing protein 6 with...
| Keywords: | BLU-667,... |
| Application: | RET inhibitor |
| CAS | 2097132-94-8 |
| MW: | 533.6 D |
From 66.00€
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