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Item number: Cay37025-10

MELK-8a is an inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 0.002 µM). It is selective for MELK over FLT3, haspin, KIT, and PDGFRalpha, (IC50s = 0.18, 0.19, >10, and 0.42 µM, respectively), as well as a panel of 456 kinases at 1 µM. MELK-8a inhibits the proliferation of MDA-MB-468 and MCF-7...

Keywords:	NVS-MELK8a, 1-methyl-4-[4-[4-[3-(4-piperidinylmethoxy)-4-pyridinyl]-1H-pyrazol-1-yl]phenyl]-piperazine, monohydrochloride
Application:	MELK inhibitor
CAS	2096992-20-8
MW:	469 D

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