2 products were found matching "2095719-92-7"!

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Item number: TGM-T8472-100mg

Description: ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity. Target: ERK. Smiles: O=C1C=2C(CN1[C@@H](C(N[C@H](CO)C3=CC(OC)=CC(F)=C3)=O)C)=CC=C(C2)C4=NC(NC5CCOCC5)=NC=C4Cl

Keywords:	ASTX-029, ASTX029
Application:	ERK1/2 inhibitor
CAS	2095719-92-7
MW:	584.04 D

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ASTX029

Item number: Cay33557-1

ASTX029 is an ERK inhibitor (IC50 = 2.7 nM for ERK2). It is selective for ERK over a panel of 465 kinases. ASTX029 reduces phosphorylation of p90 ribosomal S6 kinase (RSK) in mutant B-RAF-expressing A375 melanoma and mutant K-Ras-expressing HCT116 colorectal cancer cells with IC50 values of 3.3 and 4 nM,...

Keywords:	(alphaR)-6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethy...
Application:	ERK inhibitor
CAS	2095719-92-7
MW:	584 D

From 85.00€ *

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Review

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