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Item number: AG-CR1-3754-M001

VX-745 is a potent inhibitor of p38alpha MAPK (IC50=10nM) with 20-fold selectivity over p38beta and 1000-fold selectivity over closely related kinases, ERK1, MK2 and JNK1-3. p38alpha is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases and is widely expressed in...

Keywords:	5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one, Neflamapimod, VX745
Application:	p38 alpha inhibitor
CAS	209410-46-8
MW:	436.3 D

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Neflamapimod

Item number: TGM-T6089-100mg

Description: Neflamapimod (VX-745) , a specific and effective inhibitor of p38alpha(IC50=10 nM), is 22-fold greater specificity against p38beta and no inhibition activity to p38gamma. Target: Autophagy, p38 MAPK. Smiles: Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1. References: Decicco C, et al. American...

Keywords:	VX-745
Application:	Targets p38 MAP kinase [EC:2.7.11.24] (P38)
CAS	209410-46-8
MW:	436.26 D

From 41.00€ *

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