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Item number: TGM-T5374-100mg

Description: NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM). Target: E1/E2/E3 Enzyme, NEDD8. Smiles: CCCCN1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1. References: Scott DC, et al. Blocking an N-terminal acetylation-dependent protein interaction inhibits an...

CAS	2089293-61-6
MW:	434.4 D

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NAcM-OPT

Item number: Cay42379-10

NAcM-OPT is an inhibitor of the protein-protein interaction between ubiquitin-protein ligase E2M (UBE2M) and DCN1-like protein 1 (DCNL1, IC50 = 0. µM in a time-resolved FRET (TR-FRET) assay). It is selective for DCNL1 over DCNL3, DCNL4, and DCNL5 (IC50s = >50 µM) but does inhibit DCNL2 at 12. µM. NAcM-OPT (10 µM)...

Keywords:	N-(1-butyl-4-piperidinyl)-N'-(3,4-dichlorophenyl)-N-(phenylmethyl)-urea
Application:	UBE2M-DCNL1 protein-protein interaction inhibitor
CAS	2089293-61-6
MW:	434.4 D

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